What is Lyme disease? -- The early history and epidemiologic surveillance -- What are the symptoms and signs of Lyme disease? -- What do the diagnostic tests tell us? -- The great divide and the Lyme wars -- Why would symptoms persist after antibiotic treatment for Lyme disease? -- What are the treatments for Lyme disease? -- Other tick-borne infections -- What other noninfectious diseases have Lyme-like symptoms? -- Lyme disease prevention and transmission -- Suggestions to the patient in seeking evaluation or treatment -- The experience of the patient with chronic symptoms -- Frequently asked questions -- The good news emerging from Lyme disease research